Talos by Antaeus Labs
TALOS was a mythological figure in ancient Greece – a giant man of bronze who protected the shores of Crete from invaders. Now you can harness the power of Talos to support your cardiovascular system.
The Talos formula promotes cardiovascular health in all users, though it is specifically designed to help combat the negative effects of exogenous administration of androgens. Talos seeks to combat the adverse health effects of self-administered anabolic steroids, designer steroids, and prohormones with a combination of antioxidants, vitamins, and potent herbal extracts.
Anthocyanins – Black Rice extract has been replaced with Sour Cherry extract. Like black rice, sour cherry is loaded with anthocyanins.
It has long been known that androgens cause an adverse shift the ratios of lipoproteins; causing an increase in low-density lipoproteins (LDL) and a reduction in high-density lipoproteins (HDL). This is due to an increase in postheparin plasma hepatic triglyceride lipase (HTGL) activity; HTGL is the enzyme responsible for the catabolism of HDL. High LDL and low HDL levels are associated with atherosclerosis and heart disease.
Anthocyanins have been shown to increase HDL and reduce LDL concentrations in humans, which may be due to the inhibition of plasma cholesteryl ester transfer protein (CETP), an enzyme which transfers cholesterol from HDL cholesterol to very low density or low density lipoproteins.
There’s also evidence that the hypolipidemic effects of anthocyanins may be due to increased CYP7A1 expression due to agonism of LXRα.
“Our results suggest that anthocyanin supplementation in dyslipidemic patients has a beneficial effect on the lipoprotein profile, which includes a decrease in LDL-cholesterol and an increase in HDL-cholesterol concentrations.”
Matrine – Soon after the introduction of oral (17a-alkylated) steroids it became apparent that excessive doses or prolonged use can be deleterious to liver function, and since then there have been several case studies of jaundice and liver failure secondary to oral steroid use – both self-administered and in the clinical setting. The hepatotoxic effects of oral androgens are of a primarily cholestatic nature.
Matrine has been shown in animal models to have a powerful protective effect against cholestasis caused by steroids and other drugs.
Trans-Resveratrol the naturally-occurring grape-derived antioxidant and phytoestrogen trans-resveratrol is believed to be cardioprotective through a number of mechanisms; amongst other things, it inhibits lipid peroxidation, induces vasorelaxation, and limits oxidative damage through the reduction of reactive oxygen species (ROS).
“Resveratrol, a grape polyphenol, has shown considerable promise as a therapeutic agent in the treatment of liver ailments. Several studies have highlighted the hepatoprotective properties of resveratrol. Resveratrol has been shown to prevent hepatic damage because of free radicals and inflammatory cytokines, induce anti-oxidant enzymes and elevate glutathione content.”
9-Cis-B-Carotene – Dunaliella salina extract, containing 10% 9-Cis-Beta Carotene. Beta Carotene is the pigment that gives carrots their orange colour, and is a precursor to vitamin A, which is good for the skin. In the form of 9-Cis-B-Carotene, it is also anti-atherogenic (in animal models).
Salicin is a pro-drug to salycilic acid. Administration of anabolic steroids or prohormones enhances platelet aggregation. Salicylic acid decreases platelet aggregation by inhibiting the formation of thromboxane A2, reducing the risk of blood clots, heart attack and stroke.
B9, B6, and B12 – Androgens like testosterone have been shown to increase levels of homocysteine, and the self-administration of anabolic steroids can increase homocysteine levels dramatically.
Homocysteine damages the structure of the arteries, and hyperhomocysteinemia (high homocysteine levels) is a strong risk-factor for cardiovascular disease, blood clots, and strokes.
Folic acid (B9), pyridoxine (B6), and cobalamin (B12) reduce the levels of homocysteine.
Astaxanthin promotes healthy lipid metabolism as an antioxidant, as a PPAR-α agonist, and also by promoting expression of ATP-binding cassette transporters A1 and G1 (ABCA1/G1). ABCA1 and ABCG1 mediate the efflux of cholesterol; helping to remove lipids from cells as the initial step in reverse cholesterol transport (RCT). RCT is the process by which cholesterol is shuttled back to the liver by HDL.
“RCT is a pathway that transports cholesterol from extrahepatic cells and tissues to the liver and intestine for excretion. By reducing accumulation of cholesterol in the wall of arteries, RCT may prevent development of atherosclerosis. Cholesterol efflux, part of the RCT process, is a major process by which macrophages within the vessel wall secrete cholesterol outside cells.”
Cepharanthine is a naturally-occurring alkaloid extracted from Stephania cepharantha. It scavenges free radicals, inhibits platelet aggregation, and is anti-inflammatory (through the inhibition of histamine release from mast cells).
Coenzyme A is important to a number of the body’s metabolic functions (like the oxidation of fatty acids). Supplementation has the potential to improve a number of end-points, including acne, and triglycerides. Crystalline Coenzyme A is stable for several years at room temperature.
Serving Size: 1 Capsule
Servings per Container: 120
Prunus Cerasus 20:1 extract 200mg *
Matrine 125mg *
Trans-Resveratrol 50mg *
Dunalielia salina extract, 10% 9-Cis-Beta Carotene 37.5mg *
Salicin 37.5mg *
Vitamin B6 15mg *
Astaxanthin 4.15mg *
Vitamin B9 1.25mg *
Cepharanthine 825mcg *
Coenzyme A 400U *
Vitamin B12 50mcg *
* Daily Value not established
Other Ingredients: Gelatin, Silicon Dioxide, Microcrystalline Cellulose.